Laugier-Hunziker Syndrome (LHS)

What is Laugier-Hunziker Syndrome (LHS)

Laugier-Hunziker Syndrome (LHS) is a rare disorder that affects the pigment of the skin and mucous membranes of the mouth. LHS is also known as idiopathic lenticular mucocutaneous pigmentation.

LHS is a benign (non-cancerous) condition and does not cause any serious health problems. The main symptom of LHS is the appearance of dark pigmentation on the lips, inside of the mouth, and sometimes on the fingers and toes. The pigmentation is typically brown or black and appears as small, flat spots or patches.


The exact cause of LHS is unknown, but it is thought to be a combination of genetic and environmental factors. Some cases of LHS have been associated with mutations in the TERT gene, which is involved in the process of cell division and aging. Other cases have been linked to exposure to certain medications, such as nonsteroidal anti-inflammatory drugs (NSAIDs) and hormonal therapies.


LHS is usually diagnosed based on the pigmentation pattern which is characteristic of the disorder, as well as a thorough medical history. In some cases, a skin biopsy may be performed to rule out other conditions that may cause similar symptoms.


Treatment for LHS is usually not necessary as the condition does not cause any health problems. However, if the pigmentation is causing cosmetic concerns, treatment options such as laser therapy, cryotherapy, and topical creams may be considered.

It is important to note that LHS does not increase the risk of developing skin cancer or other health problems. However, it is still important to practice good sun protection habits, such as wearing protective clothing and sunscreen, to prevent damage to the skin



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