Julie Scott, DNP
Julie Scott, DNP
Amyloidosis | cancerGO

What is Amyloidosis?

Amyloidosis is a rare condition that occurs when an abnormal protein, called amyloid, builds up in the body’s organs and tissues. Over time, this buildup can cause damage and lead to organ failure. Here’s an overview of the symptoms, diagnosis, and treatment of amyloidosis.


The symptoms of amyloidosis can vary depending on which organs or tissues are affected. Some common symptoms include:

  • Fatigue
  • Shortness of breath
  • Swelling in the ankles and legs
  • Numbness or tingling in the hands or feet
  • Weight loss
  • Diarrhea or constipation
  • Enlarged tongue
  • Skin changes
  • Irregular heartbeat
  • Kidney problems


To diagnose amyloidosis, a doctor will perform a physical exam, review the patient’s medical history, and order various tests. These may include:

  • Blood tests to measure levels of abnormal proteins and assess the function of organs such as the kidneys and liver
  • Urine tests to check for abnormal proteins and assess kidney function
  • Imaging tests such as X-rays, CT scans, or MRI scans to visualize the organs and tissues
  • Biopsy, where a sample of tissue is taken from the affected area and examined under a microscope to look for signs of amyloid deposits


The treatment for amyloidosis depends on the type of amyloidosis, the extent of organ damage, and the patient’s overall health. The goal of treatment is to slow down or stop the progression of the disease and manage symptoms. Some common treatments for amyloidosis include:

  • Chemotherapy: Chemotherapy drugs may be used to kill off the abnormal cells that produce amyloid deposits.
  • Immunomodulatory drugs: These drugs help regulate the immune system and may help slow down the production of amyloid.
  • Stem cell transplant: In some cases, a patient may receive high-dose chemotherapy and then a stem cell transplant to help rebuild healthy blood cells.
  • Organ transplant: For patients with advanced organ damage, an organ transplant may be necessary to replace the damaged organ.
  • Supportive care: Other treatments may be used to manage symptoms such as pain, swelling, and organ dysfunction. These may include medications, dietary changes, and other supportive therapies.


The prognosis for amyloidosis depends on many factors, including the type of amyloidosis, the extent of organ damage, and the patient’s overall health. Some types of amyloidosis are more aggressive and may have a poorer prognosis. In general, early detection and treatment are important for improving the outlook of people living with amyloidosis.


Julie Scott, DNP
Julie Scott, DNP
Julie is an oncology certified Oncology Nurse Practitioner with over a decade of medical oncology experience. In addition to her clinical work, she is an accomplished healthcare writer providing oncology content for various publications. She also serves as an adjunct faculty member for a Master's nursing program and a chair for Doctoral nursing students.

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