Cholangiocarcinoma – An Overview of Causes, Symptoms, Treatment, and Prevention

Cholangiocarcinoma – An Overview of Causes, Symptoms, Treatment, and Prevention

Julie Scott, DNP
Julie Scott, DNP
Cholangiocarcinoma | cancerGO

What is Cholangiocarcinoma?

Cholangiocarcinoma, also known as bile duct cancer, affects the bile ducts, which are the tubes that carry bile from the liver to the small intestine. Cholangiocarcinoma is a relatively rare form of cancer but can be very aggressive.

Risk Factors

Although there isn’t one specific cause of cholangiocarcinoma, some known associated risk factors exist.

  • Increasing age
  • Male sex
  • Having a history of cirrhosis, or scarring, of the liver
  • Having a history of primary sclerosing cholangitis (PSC), which is a chronic inflammation of the bile duct
  • Family history of cholangiocarcinoma

Symptoms

The exact symptoms of cholangiocarcinoma may vary from each person. Some common side effects can include:

  • Jaundice, a yellowing of the skin and whites of the eyes
  • Itching of the skin
  • Fatigue
  • Weight loss
  • Abdominal pain
  • Nausea and vomiting
  • Clay-colored stools
  • Dark urine

Diagnosis

If someone presents to their healthcare provider with the above symptoms, an evaluation of the cause of these symptoms can include imaging studies. Studies such

MRI, CT scan, or ultrasound can picture the liver and bile ducts to look for abnormalities.

A specialized scan called an endoscopic retrograde cholangiopancreatography (ERCP) can be done. This procedure uses an endoscope (a long, flexible tube with a camera on end) and X-ray imaging to visualize the bile ducts and take samples for testing.

Ultimately a biopsy, in which a small sample of tissue is taken from the suspected tumor, is done to confirm the diagnosis of cholangiocarcinoma.

Treatment

The treatment plan will vary depending on the stage and location of cancer, as well as the overall health of the patient. Treatment options for cholangiocarcinoma include:

  • Surgery: Surgery to remove the tumor is the primary treatment for cholangiocarcinoma. The type of surgery will depend on the location and stage of cancer.
  • Radiation therapy: Radiation therapy uses high-energy beams to kill cancer cells. It may be given alone or in combination with surgery.
  • Chemotherapy: Chemotherapy uses drugs to kill cancer cells. It may be given alone or in combination with radiation therapy.
  • Palliative care, which focuses on relieving symptoms and improving quality of life, is often necessary for advanced cases of cholangiocarcinoma.

 

Cholangiocarcinoma is a rare but aggressive cancer that forms in the bile ducts. If you think you may be at risk for developing this disease, speak with your doctor about steps you can take to lower your risk. There are also treatment options available if you are diagnosed with cholangiocarcinoma. With prompt diagnosis and treatment, patients can often achieve remission or slow the progression of their disease.

Julie Scott, DNP
Julie Scott, DNP
Julie is an oncology certified Oncology Nurse Practitioner with over a decade of medical oncology experience. In addition to her clinical work, she is an accomplished healthcare writer providing oncology content for various publications. She also serves as an adjunct faculty member for a Master's nursing program and a chair for Doctoral nursing students.

Download our
mobile app

Share this post
You may also like
Announcements
When You Have Cancer: The Importance of Relationships
October 31, 2022

All of us understand the importance of our relationships. We always need each other, but we need one another even more than usual when faced with a crisis. Cancer certainly qualifies as a people-needing time. Cancer Human Resources 101 If there were a required introductory course for newly diagnosed cancer…

admin

administrator

Articles
Characteristics of breast cancer
November 8, 2022

Characteristics of breast cancer When a biopsy is done, and cancer has been confirmed, there are additional things the oncologist needs to know about the cancer.  Hormone receptor status: This determines if the cancer cells use either estrogen or progesterone (or both) to grow. If there are estrogen receptors on…

Julie Scott, DNP

author

Articles
Wilms tumor
March 1, 2023

What is Wilms tumor? Wilms tumor, also known as nephroblastoma, is a rare type of kidney cancer that mainly affects children. In this article, we will discuss the symptoms, risk factors, diagnosis, and treatment of Wilms tumor. Symptoms The most common symptom of Wilms tumor is a painless swelling or…

Julie Scott, DNP

author

cancerGO gives you access to a community

Where are people to listen, answer questions, share information, and offer valuable and timely advice